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Huntington's Disease Youth Organization

Is HD gene on the X chromosome?

HDYO has more information about HD available for young people, parents and professionals on our site:

www.hdyo.org

Q. Father inherited HD from his mother. Therefore, will everyone of his female offspring inherit the HD gene due to the ‘X’ chromosome contributed by the father, making probability 100% vs. 50%?

MJ, Young Adult, USA

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A. Hi MJ,

Thanks very much for sending a question about how HD is passed on in families. The HD gene is actually not on the X-chromosome (it’s on Chromosome no 4) and so the risks are the same for males and females. Therefore in the example you gave of a father inheriting HD from his mother, each child, whether male or female, will have a 50% risk of inheriting the condition (or to put it another way an equal chance of not inheriting the condition). Do you have a family history of HD MJ? If so, & you would like to ask more questions, do email again.

All the best,

Rhona