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Is it possible no children will inherit HD?

September 30, 2015

Huntington's Disease Youth Organization

HDYO has more information about HD available for young people, parents and professionals on our site:


Is it possible no children will inherit HD?

Q. My mother is 55 years old and has HD from the last 16 years, we are three siblings, I am aware that every child has a 50:50 chance of inheriting this disease but have you ever came across a family where not even one child inherited it?

Ayesha, Young Adult, Pakistan

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A. Hi Ayesha,

Thanks for your email and sharing your question. You are right in thinking that you and your siblings each have a 50:50 chance of inheriting HD from your mother (or to put it another way, an equal chance of not inheriting HD).

Yes, we do come across families where by chance none of the children have inherited the HD gene fault. This is because you each have a completely independent 50:50 risk, (if you toss a coin 3 times it is quite possible for it to land the same way three times in a row). You may find this article useful.

How do you cope with being at risk Ayesha? Is it something that you and your siblings discuss? We hope you find the information on this website useful.

If you have any further questions, please get in touch.

Best wishes,